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Hot Melt Extrusion (HME)

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Type of extrusion that uses compaction and conversion of blends from a powder or a granular mix into a product of uniform shape. HME has several potential advantages over traditional processing techniques such as spray drying or roll spinning, including the absence of solvents, reduced processing steps, continuous operation, and the possibility to form solid dispersions and improve bioavailability. Commonly used in plastic, rubber and food manufacturing industries.

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